Studies on the Action of Synthetic Antimalarial Drugs on Indian Strains of Malaria

Cilional was introduced by Schulemann of Messrs. Bayer-Meister-Lucius, Germany, a few years ago. It belongs to the plasmochin series of preparations and has the composition di-alkylamino-alkyl-amino-oxy-quinoline. Its action on the gametocyte of Plasmodium falciparum was claimed to be as potent as that of plasmochin, in doses far less than, any that produced toxic symptoms. A total dose of 0.18 to 0.3 gramme (in daily doses of 0.06 gramme) proved sufficient to make the crescents disappear from the 'peripheral blood. Atebrin was also given at the same time